Antioxidant Activity and Toxic Effects of Phosphorus-Containing Derivatives of 2,6-Di-tert-Butylphenol in silico and in vitro, in vivo

  • Maria Aleksandrovna Polovinkina Astrakhan State Technical University
  • Victoria Pavlovna Osipova Southern Scientific Center, Russian Academy of Sciences
  • Margarita Nikolaevna Kolyada Southern Scientific Center, Russian Academy of Sciences
  • Anastasia Dmitrievna Osipova Astrakhan State Technical University.
  • Nadezhda Titovna Berberova Astrakhan State Technical University
  • Yuri Timofeevich Pimenov Astrakhan State Technical University.
  • Elena Rudolfovna Milaeva Lomonosov Moscow State University.
Keywords: phosphor substituted derivatives, 2, 6-di-tert-butylphenol, toxicity, in silico, antioxidant, in vitro, Russian sturgeon, in vivo, fish feeds, lipid peroxidation

Abstract

With the help of the PASS Online web resource, the high probability of antioxidant activity manifestation by phosphorus-containing derivatives of 2,6-di-tert-butylphenol, the ability to act as "traps" of active oxygen metabolites and heavy metal antidotes was predicted. The values of the acute toxicity index of phosphorus-containing phenols for the rats, aquatic organisms, and bioaccumulation factor, calculated by the GUSAR program, indicate potentially low toxicity. The results of the forecast are comparable with the data of experimental studies in in vitro and in vivo experiments.

DOI: http://dx.doi.org/10.5755/j01.erem.75.1.21050

Published
2019-05-22
Section
Articles