Antioxidant Activity and Toxic Effects of Phosphorus-Containing Derivatives of 2,6-Di-tert-Butylphenol in silico and in vitro, in vivo

Maria Aleksandrovna Polovinkina; Victoria Pavlovna Osipova; Margarita Nikolaevna Kolyada; Anastasia Dmitrievna Osipova; Nadezhda Titovna Berberova; Yuri Timofeevich Pimenov; Elena Rudolfovna Milaeva

doi:10.5755/j01.erem.75.1.21050

Maria Aleksandrovna Polovinkina Astrakhan State Technical University
Victoria Pavlovna Osipova Southern Scientific Center, Russian Academy of Sciences
Margarita Nikolaevna Kolyada Southern Scientific Center, Russian Academy of Sciences
Anastasia Dmitrievna Osipova Astrakhan State Technical University.
Nadezhda Titovna Berberova Astrakhan State Technical University
Yuri Timofeevich Pimenov Astrakhan State Technical University.
Elena Rudolfovna Milaeva Lomonosov Moscow State University.

DOI: https://doi.org/10.5755/j01.erem.75.1.21050

Keywords: phosphor substituted derivatives, 2, 6-di-tert-butylphenol, toxicity, in silico, antioxidant, in vitro, Russian sturgeon, in vivo, fish feeds, lipid peroxidation

Abstract

With the help of the PASS Online web resource, the high probability of antioxidant activity manifestation by phosphorus-containing derivatives of 2,6-di-tert-butylphenol, the ability to act as "traps" of active oxygen metabolites and heavy metal antidotes was predicted. The values of the acute toxicity index of phosphorus-containing phenols for the rats, aquatic organisms, and bioaccumulation factor, calculated by the GUSAR program, indicate potentially low toxicity. The results of the forecast are comparable with the data of experimental studies in in vitro and in vivo experiments.

DOI: http://dx.doi.org/10.5755/j01.erem.75.1.21050