Antioxidant Activity and Toxic Effects of Phosphorus-Containing Derivatives of 2,6-Di-tert-Butylphenol in silico and in vitro, in vivo
Keywords:
phosphor substituted derivatives, 2, 6-di-tert-butylphenol, toxicity, in silico, antioxidant, in vitro, Russian sturgeon, in vivo, fish feeds, lipid peroxidation
Abstract
With the help of the PASS Online web resource, the high probability of antioxidant activity manifestation by phosphorus-containing derivatives of 2,6-di-tert-butylphenol, the ability to act as "traps" of active oxygen metabolites and heavy metal antidotes was predicted. The values of the acute toxicity index of phosphorus-containing phenols for the rats, aquatic organisms, and bioaccumulation factor, calculated by the GUSAR program, indicate potentially low toxicity. The results of the forecast are comparable with the data of experimental studies in in vitro and in vivo experiments.
Published
2019-05-22
Issue
Section
Articles
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